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晁天柱(博士)

作者: 阅读次数: 日期:2024-11-26

学位:博士研究生

职称/职务:实验师

E-mail:chaotianzhu@126.com

研究方向:小鼠免疫遗传学

晁天柱,男,博士研究生。2017年6月于东华大学获得博士学位。2017年6月至2021年5月,在新乡医学院精神神经医学研究院从事巨噬细胞极化的分子机制研究和蛋白质新药的研发工作。2021年6月至今,在16877太阳集团实验教学中心担任实验师。主讲有机化学实验课、无机与分析化学实验课教学。

主持或参加科研项目(课题)情况:

1.浙江省神经损伤修复新靶点及药物研究重点实验室开放基金重点项目:NTD202301, Sarm1介导线粒体在微管上的锚定在阿尔茨海默病轴突变性中的作用,参与,2023-2026.

2.校企合作横向课题:63501222130,固着类纤毛虫检测试剂盒的开发,结项,负责人,2022-2023.

3.国家自然基金联合基金项目:U1904157,Gfi1突变抑制CD36阳性单核细胞亚群分化及动脉粥样硬化形成的机制,参与,2020-2022.

4.国家自然科学基金面上项目:31770824,去棕榈酰化修饰酶APT1和APT2的生理功能研究,参与,2018-2021.

5.国家自然基金面上项目:31171199,利用野生小家鼠来源1号染色体替换群体快速精细定位血脂调控基因,参与,2012-2015.

6.国家自然基金面上项目:31071090,中国野生小家鼠群体遗传结构基本框架的研究,参与,2011-2013.

近年来发表的代表性论文(“*”通讯作者):

1.Liangwei Duan, Yucong Zhao, Jing Jia,Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng*, Hui Wang*. Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis. Biochim Biophys Acta Mol Basis Dis. 2023 Jun;1869(5):166698. doi: 10.1016/j.bbadis.2023.166698. Epub 2023 Mar 23.

2.Nan Zhang, Gui-Yuan Son, Yong-Jian Hu, Xia Wang,Tian-Zhu Chao, Yao-Yao Wu, Ping Xu*. Analysis of lncRNA-miRNA-mRNA Expression in the Troxerutin-Mediated Prevention of Radiation-Induced Lung Injury in Mice. J Inflamm Res. 2023 Jun 3:16:2387-2399. doi: 10.2147/JIR.S397327. eCollection 2023.

3.Liaoxun Lu, Tianhan L, Xinyu Feng, Zhilong Liu, Yang Li,Tianzhu Chao, Yanrong Gu, Rong Huang, Fanghui Zhang, Le H, Binhui Zhou, Eryan Kong, Zhuangzhuang Li, Xugang Wang, Zhijun Chen, Hui Wang, Marie Malissen, Bernard Malissen, Lichen Zhang*, Yinming Liang*. Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice. PLoS Pathog. 2022 Jun; 18(6): e1010596.

4.Wei Yuan, Liaoxun Lu, Muding Rao, Yang Huang, Chun-e Liu, Shuang Liu, Yue Zhao, Huicong Liu, Jiangli Zhu,Tianzhu Chao, Can Wu, Junyan Ren, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Shijing Yue, Jian Gao, Zhongjian Zhang*, Eryan Kong*. GFAP hyper-palmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2022261118. doi: 10.1073/pnas.2022261118.

5.Tianzhu Chao, Liaoxun Lu, Lichen Zhang, Rong Huang, Zhuangzhuang Liu, Binhui Zhou, Eryan Kong, Zhongjian Zhang, Toby Lawrence*, Yinming Liang*.An inducible model for specific neutrophil depletion by diphtheria toxin in mice.SCI CHINA LIFE SCI,2021 Jan 6. doi: 10.1007/s11427-020-1839-3.

6.Tianzhu Chao, Zhuangzhuang Liu, Yu Zhang, Lichen Zhang, Rong Huang, Le He, Yanrong Gu, Zhijun Chen, Qianqian Zheng, Lijin Shi, Wenping Zheng, Xinhui Qi, Eryan Kong, Zhongjian Zhang, Toby Lawrence, Yinming Liang*and Liaoxun Lu*. Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice. Frontiers in Genetics. 19 February 2019. Doi: 10.3389/fene.2019.00124.

7.Tianzhu Chao, Huiqiang Cai, Yuxun Zhou, Kai Li and Junhua Xiao.Subspecies Distribution of the House Mouse Mus musculus (Rodentia: Muridae) in East China as Inferred from Mitochondrial D-loop. PAKISTAN JOURNAL OF ZOOLOGY.,2017.49.4.1175.1184. (第一作者,四区,IF:0.6)

8.Fuyi Xu#,Tianzhu Chao, Yiyin Zhang, Shixian Hu, Yuxun Zhou, Hongyan Xu, Junhua Xiao, Kai Li.Chromosome 1 Sequence Analysis of C57BL/6J-Chr1KM mose strain. International Journal of Genomics. 2017;2017:1712530. doi: 10.1155/2017/1712530.

9.Wenyi Yang, Binhui Zhou, Qi Li, Taozhen Li, Huijie Wan, Pei Zhang, Liaoxun Lu, Lichen Zhan, Fanghui Zhang, Rong Huang, Jitong Zhou, Tianzhu Chao, Yanrong Gu, Songhua Lee, Hui Wang, Yinming Liang, Le He. A Murine Point Mutation of Sgpl1 Skin Is Enriched With Vγ6 IL17-Producing Cell and Revealed With Hyperpigmentation After Imiquimod Treatment. Front Immunol. 2022 Jun 13:13:728455. doi: 10.3389/fimmu.2022.728455. eCollection 2022.

10.Lichen Zhang, Wushan Li, Zhuangzhuang Liu, Yang Liu, Zhilong Liu, Yanrong Gu, Le He, Binhui Zhou, Tianhan Li, Tianzhu Chao, Yinming Liang, Liaoxun Lu. sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification. Front Cell Dev Biol. 2022 Jan 18:9:769673. doi: 10.3389/fcell.2021.769673. eCollection 2021.

11.Qianqian Zheng, Liangwei Duan, Yunwei Lou,Tianzhu Chao, Guo Guo, Liaoxun Lu, Hongxia Zhang, Yucong Zhao, Yinming Liang, Hui Wang. Slfn4 deficiency improves MAPK-mediated inflammation, oxidative stress, apoptosis and abates atherosclerosis progression in apolipoprotein E-deficient mice.Atherosclerosis. 2021 Oct 16:337:42-52. doi: 10.1016/j.atherosclerosis.2021.10.010.

12.Liaoxun Lu, Junjian Hu,Tianzhu Chao, Zhijun Chen, Zhuangzhuang Liu, Xinsong Luo, Yinming Liang, Pei He, and Lichen Zhang. Loss of natural resistance to schistosome in T cell deficient rat. PLoS Negl Trop Dis. 2020 Dec 21;14(12):e0008909. doi: 10.1371/journal.pntd.0008909.

13.Binhui Zhou, Wenyi Yang, Wushan Li, Le He, Liaoxun Lu, Lichen Zhang, Zhuangzhuang Liu, Ying Wang,Tianzhu Chao, Rong Huang, Yanrong Gu, Tingting Jia, Qiaoli Liu, Shuanghua Tian, Philippe Pierre, Takahiro Maeda, Yinming Liang, Eryan Kong. Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis. Front Immunol. 2021 Jan 8:11:607442. doi: 10.3389/fimmu.2020.607442. eCollection 2020.

14.Guo Guo, Rui Fu, Lichen Zhang,Tianzhu Chao, Zhenzhen Jiang, Linwei Dong, Rong Huang, Liaoxun Lu, Wenyi Yang, Yanrong Gu, Yinming Liang, Qianqian Zheng. Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-κB activation during inflammation in macrophages. Mol Immunol. 128(2020) 219–226.

15.Huijie Wang, Saichao Li,Tianzhu Chao, Xugang Wang, Lijin Shi, Lichen Zhang, Yinming Liang, Qianqian Zheng, Liaoxun Lu. A point mutation in the extracellular domain of CD4 completely abolishes CD4 T cell development in C57BL/6J mouse. Mol Immunol. 2017 Dec;92:12-20.

16.Fuyi Xu, Shixian Hu,Tianzhu Chao, Maochun Wang, Kai Li, Yuxun Zhou, Hongyan Xu, Junhua Xiao. Sequence analysis of chromosome 1 revealed different selection patterns between Chinese wild mice and laboratory strains. Mol Genet Genomics. 2017 Jun 19. doi: 10.1007/s00438-017-1335-z.

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